Indianapolis, IN -- (Sports Network) - Indianapolis Colts superstar quarterback Peyton Manning underwent a procedure Monday afternoon to have an infected bursa sac removed from his left knee, and will be out of action for four to six weeks, team president Bill Polian announced in a statement.

Polian said that Manning, the NFL's Most Valuable Player in 2003 and 2004, had been receiving conservative treatment for an inflamed bursa sac since February, but he began to experience increased pain and showed early signs of infection.

The first overall selection in the 1998 draft by the Colts, Manning has never missed a regular season start in 10 pro seasons. The eight-time Pro Bowl selection threw for 4,040 yards and 31 touchdowns last season and led Indy to the AFC South title.

In 160 career regular season games, the Tennessee product has thrown for 41,626 yards and 306 touchdowns. He has eclipsed the 4,000 yard passing mark in eight of the last nine seasons and has tossed at least 26 scoring strikes in each season of his career.

Manning's 94.7 passer rating leads all active quarterbacks and ranks second all-time behind Steve Young (96.8).