2009 Pittsburgh Panthers Schedule
| Date | Time (ET) | Opponent | Result | Record |
| 09/05/2009 | 01:00 PM | Youngstown St | W, 38-3 | 1-0-0 |
| 09/12/2009 | 12:00 PM | at Buffalo | W, 54-27 | 2-0-0 |
| 09/19/2009 | 06:00 PM | Navy | W, 27-14 | 3-0-0 |
| 09/26/2009 | 03:30 PM | at NC State | L, 38-31 | 3-1-0 |
| 10/02/2009 | 08:00 PM | at Louisville | W, 35-10 | 4-1-0 |
| 10/10/2009 | 03:30 PM | Connecticut | W, 24-21 | 5-1-0 |
| 10/16/2009 | 08:00 PM | at Rutgers | W, 24-17 | 6-1-0 |
| 10/24/2009 | 12:00 PM | So Florida | W, 41-14 | 7-1-0 |
| 11/07/2009 | 12:00 PM | Syracuse | W, 37-10 | 8-1-0 |
| 11/14/2009 | 08:00 PM | Notre Dame | W, 27-22 | 9-1-0 |
| 11/27/2009 | 07:00 PM | at West Virginia | ||
| 12/05/2009 | 12:00 PM | Cincinnati |
